In the recessive inheritance model, there was a significant protective effect between the MDM4 (GG + GA) and MDM4 -AA genotypes that reduced breast cancer susceptibility (OR = 0.46 (CI = 0.2598–0.8326), RR = 0.64 (0.4561–0.9060), and p = 0.010) (Table 7). The gene discussed is MDM4; the disease is breast carcinoma.