The frequencies of MDM4 rs11801299 G > A and KLF-14 rs972283 A > G genotypes determined in the cases of breast cancer and gender matched healthy controls (Table 3).Results showed that the AA genotype of the KLF-14-rs972283 A > G was associated with BC (Table 3), Moreover, the results indicated that the KLF-14 (rs972283 A > G) SNP genotype was significantly different in cases at early sate and cases at advance stage (Table 10). The gene discussed is MDM4; the disease is breast carcinoma.