In the dominant inheritance model, there is a significant association between the KLF14-GG and KLF14-(GA + AA) genotypes and leads to increased breast cancer susceptibility with OR = 1.87 (CI = 1.07–3.26), RR = 1.87 (CI = 1.0465–1.7336), and p < 0.026. This evidence concerns the gene KLF14 and breast cancer.