Our findings reported a strong association between the AKT1 rs1130233-GA genotype with the breast cancer susceptibility in the codominant model, with an OR of 3.20 (95%) CI = (1.6829 to 6.084), RR = 1.84 and p< 0.0004 and AKT1 rs1130233-AA genotype was strongly linked to breast cancer susceptibility with an OR of 3.20 (95%) CI = (1.682 to 6.084), RR = 3.69 and p < 0.044. This evidence concerns the gene AKT1 and breast cancer.