In one of the studies reported that the whole body loss of KLF14 function in male mice does not result in metabolic abnormalities as assessed under chow and HFD conditions and concluded that there is redundancy for the role of KLF14 in the mouse and a diverging function in human malignancies [61]. It was reported that KLF14/miR-1283 signaling is downregulated cell proliferation in HER2+ breast cancer. This evidence concerns the gene ERBB2 and breast cancer.