Neutrophils assist cancer cells in escaping the antitumor immune response through the overexpression of immune checkpoint molecules, including programmed death ligand 1 (PD-L1) [175], glucocorticoid-induced tumor necrosis factor receptor-related protein-ligand (GITRL) [176], and V-domain Ig suppressor of T cell activation (VISTA) [177]. The gene discussed is CD274; the disease is cancer.