Quite recently Matikas et al. found a significant association of CK19 mRNA positive CTCs and 10-year overall survival, disease-free survival, as well as correlations with larger tumor size and positive lymph nodes in a cohort of 1220 early and locally advanced breast cancer patients by using a comparable CK19 primer/probe system as in the present study [5]. The gene discussed is KRT19; the disease is breast cancer.