In the first observational prospective study addressing this issue, we showed that performing radical prostatectomy on patients with a suspicious DRE, aPSA value ≥10 ng/mL, high suspicion of PCa on mpMRI (PI-RADS 4 or 5), and high suspicion of PCa on PSMA-PET imaging (CT or MRI) through local uptake of PSMA-ligand led to the diagnosis of clinically significant PCa in all patients. The gene discussed is FOLH1; the disease is posterior cortical atrophy.