BTLA and melanoma: The expression of ICs such as BTLA, TIGIT, PD-1, TIM-3, CD39, LAG-3, and NKG2A in γδ T cells has been observed in different solid and hematological tumors, including melanoma, neuroblastoma, CRC, breast cancer, OC, MM, AML, and lymphomas, and is associated with the aberrant activation and/or proliferation of γδ T cells [29,76,108,109] For instance, BTLA was found to be highly expressed by Vδ2 T cells in the lymph nodes of patients with lymphoma and could suppress their proliferation upon ligation by HVEM on primary tumors [110].