Since SCS CD169+ macrophages in lymph nodes have a functional localization surrounding B cell follicles and are associated with a beneficial prognosis in cancer patients, we first set out to investigate the localization pattern of PT-infiltrating CD169+ macrophages (CD169+ TAMs) in relation to CD20+/CD3+ B/T cell clusters (referred to as TLLSs) in primary breast cancer tumors (Figure 1B). Here, SIGLEC1 is linked to cancer.