This result either implies that the harmful prognostic effect of immune cell infiltration seen in PTs cancels out the beneficial prognostic effect seen in LNMs, or that infiltration of CD169+ TAMs into PTs is concurrent with the depletion of CD169+ macrophages from the LNMs in breast cancer patients with a higher tumor grade, therefore giving rise to worse prognosis within our cohort that only includes patients with advanced breast cancer. Here, SIGLEC1 is linked to neoplasm.