In the same year, Yen et al. studied the exosome profile in the peripheral blood of 61 GC patients, which showed a positive association between the expression of TGF-β1 and TNM stage (p = 0.03) and lymph node metastasis (p = 0.01). The gene discussed is TGFB1; the disease is metastatic malignant neoplasm in the lymph nodes.