Exosomal RPPH1 expression was significantly higher in CRC patients and significantly decreased following surgical resectionDiagnostic power of RPPH1 (AUC = 0.856) was better than CEA (AUC = 0.790), CA 19-9 (AUC = 0.544) and CA 125 (AUC = 0.654). The gene discussed is RPPH1; the disease is colorectal carcinoma.