Similar observations of improved predictive accuracy when combining exosomal biomarkers with traditional tumor markers were observed in a study by Liu et al. In this study, exosomal lncRNA CRNDE-h was found to be higher in CRC patients compared with those with benign colon diseases and HCs (AUC = 0.892), and when combined with CEA, the diagnostic accuracy improved (AUC = 0.913) [25]. The gene discussed is CEACAM5; the disease is colorectal carcinoma.