MUC16 and ovarian cancer: Whilst our study suggests a comparable accuracy to CA125, urine biomarkers are not intended to replace CA125 and imaging in secondary care; however, if our findings were confirmed in larger populations, urine biomarkers may have a role in triaging symptomatic women for additional testing in the community and in low-resource settings, or as a home-based monitoring tool for women at high risk of developing ovarian cancer.