Germline mutations in genes involved in developmental signaling pathways, such as APC (associated with familial adenomatous polyposis (FAP) syndrome), TP53 (linked to Li-Fraumeni syndrome), SUFU, and PTCH1 (manifestation of Gorlin syndrome) confer a significantly high risk of developing medulloblastoma [124]. This evidence concerns the gene PTCH1 and nevoid basal cell carcinoma syndrome.