MYC and brain neoplasm: While mice overexpressing the gene combinations GFI1 + c-MYC (GM) and OTX2 + c-MYC (OM) induced brain tumors, only the latter combination developed medulloblastoma clustered with Group 3 subtype (Figure 4B), highlighting the role of OTX2 and c-MYC as the medulloblastoma driver genes.