It is interesting to observe that all 12 drivers except ARHGAP5 (2.2%) belong to known pathways for NPC (Supplementary Figure S1e), and we noticed that autophagy- and immune-related pathways are particularly enriched for novel drivers, suggesting that larger cohort sizes from integrative analysis empowered higher statistical power in detecting rare drivers in known pathways for NPC. The gene discussed is ARHGAP5; the disease is nasopharyngeal carcinoma.