METTL3 and lung adenocarcinoma: For instance, in lung adenocarcinoma, high HNRNPC and IGF2BP3 levels correlate with reduced overall survival [156,157], and a six-gene risk signature (KIAA1429, ALKBH5, METTL3, HNRNPC, YTHDC2, and YTHDF1) strongly correlated with various clinical and pathological features [158].