Multivariate analysis showed that the following variables were associated with elevated AFP levels: female gender (OR = 1.462; 95% CI = 1.256–1.701; p < 0.001); tumor size per 10 mm increase (OR = 1.155; 95% CI = 1.127–1.183; p < 0.001); multiple tumors (OR = 1.406; 95% CI = 1.205–1.641; p < 0.001); BCLC stages B–D (OR = 1.247; 95% CI = 1.037–1.500; p = 0.019); cirrhosis (OR = 1.288; 95% CI = 1.099–1.509; p = 0.02); total bilirubin > 1.4 mg/dL (OR = 1.218; 95% CI = 1.020–1.455; p = 0.030); and HBV- or HCV-positive status (OR = 1.720; 95% CI = 1.451–2.038; p < 0.001) (Table 2). This evidence concerns the gene AFP and neoplasm.