Recapitulating natural ECM is crucial, as it has been demonstrated that, for example, collagen-rich, TGF-β-dependent ECM is associated with a poor prognosis in many cancer types [3,4,29,30] and the process of ECM secretion, physiologically similar to that occurring in wound healing, poses the basis for angiogenesis, cell proliferation, and immune-cell recruitment, and, in turn, impacts the responsiveness to antineoplastic drugs. This evidence concerns the gene TGFB1 and cancer.