EP300 and acute myeloid leukemia: For example, Ep300, but not Crebbp, plays a critical role in blocking the transformation of myelodysplastic syndrome (MDS) to AML and in controlling the balance between symmetric stem cell self-renewing divisions and stem cell depleting divisions in Nup98-HoxD13 transgenic mice, an animal model that phenotypically replicates human MDS [94] (Figure 3C).