ARID1A and colorectal cancer: Okamura et al. investigated 301 colorectal cancer cases and found that TMB-high tumors were more prevalent in ARID1A-mutant cases than in -wild type cases (41% versus 3.1%; p < 0.001); also, MSI-high tumors were more prevalent in ARID1A mutant cases than in wild type cases (32% versus 2.9%; p < 0.001) [34].