In the present study, we aim to study the following: (1) whether the expression level of miR-218-5p is downregulated, and whether EGFR and its downstream targets are upregulated in As-induced transformed (As-T) cells; (2) the role of miR-218 in As-T cell-induced carcinogenesis and angiogenesis; (3) whether EGFR is a direct target of miR-218-5p; (4) whether miR-128-5p serves as a tumor suppressor through targeting EGFR. This evidence concerns the gene EGFR and neoplasm.