The antitumor activity of metformin and phenformin in PCa cells was also reported to be potentiated by co-treating the cells with drugs shown to impair different aspects of cell metabolism, such as 2-deoxyglucose, an inhibitor of HK2 activity and inducer of intracellular ATP depletion [250]; gossypol, an inhibitor of ALDH (cytosolic aldehyde dehydrogenase) and, therefore, of cytosolic NADH production, which selectively reduces electron supply for ATP production [52]; and salicylate, the aspirin metabolite known to activate the AMPK pathway [251]. The gene discussed is HK2; the disease is posterior cortical atrophy.