Moreover, by addressing the issue of the stroma/tumor interplay in PCa, Giannoni et al. observed that CAFs induce an aggressive phenotype in PCa cells by triggering PKM2 nuclear translocation and consequent metabolic reprogramming towards oxidative phosphorylation; pharmacological targeting of PKM2 (by DASA-58) and OXPHOS activity (by metformin) significantly counteracts CAF-induced PCa cell growth in vitro and in vivo [167]. This evidence concerns the gene PKM and posterior cortical atrophy.