PKM and posterior cortical atrophy: Interestingly, by means of in vitro and in vivo models, Xu et al. recently reported a loss of MPC expression during the progression of PCa cells towards the most aggressive and AR-negative neuroendocrine phenotype (NEPC); in these models, MPC loss induces the expression of PKM2 that, in turn, translocates into the nucleus to regulate the expression of EMT markers [186].