Taken together, these data suggest that, even if most of the published data support that in the PCa models in which it is expressed and active (i.e., AR-driven hormone-sensitive and castration-resistant PCa) AR plays a pivotal role as a master regulator of the cancer cell metabolic reprogramming towards mitochondrial respiration, further studies are needed to definitely assess this issue. Here, AR is linked to posterior cortical atrophy.