CD3 ScFvs as well as ScFvs specific for several tumor-associated cell surface antigens such as CD19, CD20, CD33, B-cell maturation antigen (BCMA), CD123, and CD38, as well as for tumor antigens identified in hematological malignancies [100,103], have been generated for clinical application [100,103]. The gene discussed is CD33; the disease is neoplasm.