FLT3 and acute myeloid leukemia: It has two different types of mutations: internal tandem duplication of the juxta membrane (FLT3-ITD) and point mutation or deletion of tyrosine kinase domain (FLT3-TKD); these mutations are common in NPM1mut-AML compared to wild type and are now reclassified as an intermediate risk category per the European Leukemia Net (ELN) 2022 classification, regardless of the allelic ratio (change from ELN 2017, where NPM1mut with low ITD < 0.5 was considered as favorable risk).