FLT3 and acute myeloid leukemia: In a large retrospective pooled analysis (n = 2426) of NPM1mut-AML with low or absent FLT3-ITD, patients with adverse cytogenetics (per ENL 2017) had worse outcomes with high relapse rates, low EFS and OS, thereby offsetting the favorable outcomes of NPM1mut-AML with wild type FLT3.