Most of the immune infiltrate is located in the stroma of the tumor compared to the epithelium, and advanced MOCs exhibit greater epithelial infiltration by programmed death-ligand 1 (PD-L1)-negative macrophages and lower PD-L1-positive macrophages compared with stage I/II cancers (p-value = 0.004 and p-value = 0.014, respectively). This evidence concerns the gene CD274 and cancer.