5T4 (trophoblast glycoprotein) is highly expressed by trophoblast in addition to a wide range of solid tumours (e.g., renal, lung, breast, ovarian, endometrial, bladder, PDAC, oesophageal, gastric and colorectal carcinomas in addition to malignant mesothelioma). Here, TPBG is linked to malignant mesothelioma.