FOXP3 and neoplasm: Under the classic model, the immune system plays a dichotomous role in modulating tumour progression, where cytotoxic T cells, helper T cells, NK cells and DCs contribute to the anti-tumour response, and other cells like Foxp3+ regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) have a pro-tumorigenic effect that promotes cancer growth and invasion by producing cytokines sustaining angiogenesis and stimulating tumour cell proliferation [12].