CD274 and neoplasm: More specifically, there is a subset of B cells that is known to suppress T cell-mediated anti-tumour response by secreting suppressive cytokines like interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β), which can suppress macrophage and NK cell activities, promote the differentiation of naïve CD4+ T cells into regulatory T cells (Tregs) and upregulate the expression of immune checkpoint molecules like programmed death protein-1 (PD-1) and programmed death-ligand 1 (PD-L1) [26].