CXC motif chemokine ligand 2 (CXCL2) released by tumor cells, which in turn activates CXC chemokine receptor 2 (CXCR2), and IL-6, IL-8, and IL-1β recruit tumor-infiltrating MDSCs inducing epithelial–mesenchymal transition (EMT) and metastasis [96]. This evidence concerns the gene CXCR2 and neoplasm.