SOCS1 and melanoma: Melanoma cell-secreted exosomes enriched in miR-155 induced the reprogramming of fibroblasts into CAFs, triggering a proangiogenic switch by promoting the expression of proangiogenic factors, including VEGFa, fibroblast growth factor 2, and MMP9, by directly targeting SOCS1 and activating JAK2/STAT3 [131].