The QKI protein functions mainly through the following four mechanisms: (1) synergizing [193,194] or competing [193,195] with miRNAs to exert regulatory effects; (2) the splicing factor QKI can regulate the expression of downstream targets via selective splicing and participate in several biological processes such as cell proliferation [196,197]; (3) inducing cell cycle arrest and inhibiting cell proliferation [166,173,198]; (4) mediating EMT and participating in the process of tumor cell proliferation and metastasis [199]. The gene discussed is QKI; the disease is neoplasm.