Cancer-associated fibroblasts (CAFs) are also an important component of the tumor microenvironment, secreting microfibrillar-associated protein 5 (MFAP5), a component of elastic microfibers, which is also an oncogenic factor in a variety of tumors [180], promoting tumor cell proliferation, invasion [181], and recruiting new blood vessels [182]. Here, MFAP5 is linked to neoplasm.