Here, we summarized the evidence of the FHIT in cancers and evaluated the role of the FHIT in bridging macroevolution and microevolution and its functions in critical aspects of cancer evolutionary development (Cancer Evo-Dev), a theory developed to elucidate the mechanisms of non-resolving inflammation-induced carcinogenesis and develop suitable prophylactic and therapeutic options for malignant diseases. Here, FHIT is linked to cancer.