According to preclinical evidences demonstrating the role of statins in CAV1 inhibition, their potential role in the subsequent prevention of HER2 internalization was evaluated; in fact, a recent in vitro study demonstrated a significant correlation between lovastatin intake and increased cell plasma membrane-bound HER2, as well as an improved sensitivity to trastuzumab in HER2-positive gastric cancer [50]. The gene discussed is ERBB2; the disease is gastric cancer.