IQGAP2 and colorectal cancer: However, considering that dysregulation of Wnt signaling is necessary for the development of colorectal cancer, and nearly all CRCs exhibit abnormalities in Wnt signaling, it will be interesting to clarify if IQGAP2 plays a role in the carcinogenesis of colorectal cancer through the Wnt pathway in further research [34,35,79,122].