Moreover, Cao et al. also detected higher IQGAP3 levels in the serum of CRC patients than those in the healthy group, with higher sensitivity than carcinoembryonic antigen (CEA) and cancer antigen 19-9 (CA19-9), which are the most widely used diagnostic markers in CRC [101,103,123]. This evidence concerns the gene CEACAM5 and colorectal carcinoma.