In HNSCC, Chen et al. investigated 276 HNSCC samples via next-generation sequencing and reported that the most frequently mutated genes were TP53 (65%), PIK3CA (16.8%), CDKN2A (12.8%), HRAS (9.3%), BRAF (9.0%), EGFR (6.7%), and FGFR3 (5.8%). Here, PIK3CA is linked to head and neck squamous cell carcinoma.