HIPK2 and colonic neoplasm: Exosomal miR-1229 derived from HCT-116 colon cancer cells or from blood samples of patients with CRC triggers angiogenesis by targeting the Ser/Thr kinase HIPK2 (Homeodomain Interacting Protein Kinase 2), which acts as either a corepressor or a coactivator of transcription factors.