Recruitment of KDM4C lysine demethylase to the promoter of the transcriptional regulating factor HMGA2, leading to upregulation of effectors of EMT; protection of ADAM19 and BMP4 transcripts from miR-874/miR-1292; decreased colon cancer SW620 and Lovo cell proliferation, invasion and migration in vitro and in vivo (xenograft growth of SW480 cells and experimental liver metastasis). The gene discussed is KDM4C; the disease is colonic neoplasm.