On the other hand, the uptake of miR-146a-5p and miR-155-5p from CRC cell-derived exosomes activates CAFs through JAK2-STAT3/NF-κB signaling by targeting ZBTB2 (zinc finger and BTB domain containing 2) and SOCS1 (suppressor of cytokine signaling 1), respectively. Here, ZBTB2 is linked to colorectal carcinoma.