This includes the miR-221-3p released by the human colon cancer HCT-116 cells that triggers the proliferation, migration and tubulogenesis of endothelial cells through the depletion of SOCS3 (suppressor of cytokine signaling 3) transcripts and the subsequent upregulation of VEGFR [33] (Table 2). Here, SOCS3 is linked to colonic neoplasm.