Recruitment of KDM4C lysine demethylase to the promoter of the transcriptional regulating factor HMGA2, leading to upregulation of effectors of EMT; protection of ADAM19 and BMP4 transcripts from miR-874/miR-1292; decreased colon cancer SW620 and Lovo cell proliferation, invasion and migration in vitro and in vivo (xenograft growth of SW480 cells and experimental liver metastasis). This evidence concerns the gene HMGA2 and malignant colon neoplasm.