In this connection, the exosomes of the human colon cancer SW620 cell line that originate from lymph node metastasis are enriched in S100A8, HGF receptor MET and signal transduction molecules (Ephrin-B2, EGFR, protein jagged-1, SRC) compared with the isogenic SW480 cell line derived from the corresponding primary tumor [134]. Here, EGFR is linked to malignant colon neoplasm.