CASP2 and neoplasm: This tumor-suppressive activity might be related to the targeting of forkhead box protein M1 (FOXM1), methyl-CpG-binding domain protein 3 (MBD3), cyclin D1, kallikrein-10 (KLK10) and caspase-2 (CASP2) that are involved in cell proliferation, DNA methylation, cell cycle, carcinogenesis and apoptosis, respectively [72].