Upon multivariate COX regression analysis (stepwise method), IL-6 (b coefficient = 0.03956; adjusted Exp(b) = 1.0404; 95%CI = 1.0221–1.0589; p < 0.0001) and miniCASCO-based cachexia severity (b coefficient = 0.8685; adjusted Exp(b) = 2.3834; 95%CI = 1.1504–4.9378; p = 0.0194) significantly affected OS (Table 4). This evidence concerns the gene IL6 and Cachexia.