Research has established that m6A modifications are closely associated with many forms of cancer development, such as the promotion of stem cell self-renewal in leukemia [7], the stimulation of stem-like cell differentiation in glioblastoma [8], the promotion, proliferation, and invasion of hepatocellular carcinoma cell lines [9], disease progression in breast cancer [10], etc. However, the role of RNA binding motif protein 15 (RBM15) as a “writer” in the process of m6A modification and how it affects the progression of tumors is not yet known. The gene discussed is RBM15; the disease is leukemia.