As well as identifying extracellular matrix components and cell adhesion proteins as candidates for YB-1 mediated invasion, whole transcriptome sequencing of YB-1 knockdown MBGroup3 medulloblastoma cell lines identified a number of pathways and upstream regulators within cell death and survival and lipid metabolism cellular functions, which was further validated using publicly medulloblastoma patient cohorts. This evidence concerns the gene YBX1 and medulloblastoma.