Notable top 10 DEGs included those encoding extracellular matrix components COL8A1 and TNC and cell adhesion molecule CADM3, which have previously been associated with cellular invasion and migration in gastric cancer [27] and glioma [28,29] respectively, further supporting a function for YB-1 in the regulation of invasion/migration processes in medulloblastoma cells. Here, YBX1 is linked to central nervous system cancer.