In head and neck squamous cell carcinoma, invasive breast carcinoma, liver hepatocellular carcinoma, and kidney renal papillary cell carcinoma unaltered co-expression of CD44, iASPP, and p53 favored tumor patient survival, whereas in glioblastoma multiforme, their altered expression was associated with tumor patient survival. The gene discussed is PPP1R13L; the disease is head and neck squamous cell carcinoma.