We studied in silico the gene–gene interactions of CD44-iASPP and CD44-p53 complexes and how these interactions affect tumor survival by analyzing mRNA expression data of seven different types of cancers (Table S3 and Figure S3), including head and neck squamous cell carcinoma (n = 528), adult soft tissue sarcoma (n = 206), invasive breast carcinoma (n = 1084), lung squamous cell carcinoma (n = 487), liver hepatocellular carcinoma (n = 372), glioblastoma multiforme (n = 585), and kidney renal papillary cell carcinoma (n = 283) from the TCGA database using cBioPortal. This evidence concerns the gene TP53 and squamous cell lung carcinoma.