HIF1A and cancer: Metabolites can regulate chromatin or protein acetylation (e.g., c-MYC, HIF-1α, GAPDH, PKM2, PEPCK, 6PGD, ACLY, LCAD, and BCAT2), histone succinylation, butyrylation, lactylation, phosphorylation, citrullination, and itaconation, and further contribute to cancer progression [85].