PMEL and breast neoplasm: For example, dual-specific T cells expressing a HER2 CAR and a TCR specific for the melanocyte protein (gp100), together with an indirect recombinant vaccinia virus expressing gp100, were able to eradicate a variety of large solid tumors, including orthotopic breast tumors in immunocompetent mice expressing human HER2 in the breast and brain [114].