PRF1 and obstructive sleep apnea syndrome: While Dyugovskaya and colleagues demonstrated an amplification of inflammatory phenotypes in OSA patients, characterized by an increase in the avidity and cytotoxicity of γδ and CD8 T cells against an endothelial cell line [74,75], γδ T-cell populations from OSA patients showed reduced expression of perforin (related to cytotoxicity), which may facilitate a higher cancer incidence [76].