In a model of SIRT6-transgenic (SIRT6-Tg) mice, the authors showed that the upregulation of HIPK2 in fibrotic kidney and in tubular epithelial cells undergoing EMT is blocked by SIRT6 overexpression, with the consequent inhibition of renal interstitial fibrosis and of renal function deterioration in CKD [75]. Here, HIPK2 is linked to chronic kidney disease.