Accordingly, mRNA-lncRNA co-expression network and functional analyses in a CD44+CD24− breast cancer CSC population uncovered the lncRNA lncCUEDC1 as a negative regulator of stemness through inhibition of NANOG-associated biological functions [96], while the essential role of lncRNA lncTCF7 in retaining CSC self-renewal and tumor propagation properties was defined in relevant studies in CD13−CD133+ CSCs from hepatocellular carcinoma [97]. This evidence concerns the gene NANOG and neoplasm.