Upregulation of CD44 variable 6 (CD44v6) in CSC subpopulations isolated by aggressive pancreatic malignancies has been positively associated with distant metastasis [88], while CD133+ pancreatic CSCs are highly resistant to standard chemotherapy and prone to give lymph node metastasis [89]. The gene discussed is PROM1; the disease is metastatic malignant neoplasm in the lymph nodes.