UBE2L3 and osteosarcoma: Likewise, DCAF8 lncRNA-associated mRNA, DCAF8, is a ubiquitin-related gene that decreased in osteosarcoma tissues, and together with other ubiquitin-related genes (CORO6, UBE2L3, FBXL5, DNAI1) seem to play a significant role in the clinical outcome of osteosarcoma [69].