When and his colleagues were able to identify circRNAs, miRNAs, and mRNAs with key roles in retaining the stem cell phenotype of a CD133+/CD144+ CSC population isolated by human laryngeal squamous cell carcinoma cell lines after the construction of mRNA-miRNA-circRNA regulatory networks and functional enrichment analysis of the key genes [94]. This evidence concerns the gene CDH5 and laryngeal squamous cell carcinoma.