Of these, 12 proteins were found to discriminate between HC and PCa-ND as selected by random forest using RFECV, among which 6 were significantly (p-value < 0.05) up-regulated in PCa-ND (THBS1, C1QA, C1QC, CFHR2, IGHG1, and IGKV1-39); 3 in HC (SERPINA5, APOC2, and APOE); and 3 proteins showed statistically non-significant differential values between cases and controls (ECM1, GP5, and GP1BA; pV > 0.05). Here, C1QC is linked to posterior cortical atrophy.