For example, myeloid-derived suppressor cells (MDSCs) release VEGF and thus promote angiogenesis by increasing the levels of IL- l0, MMP-9, and Bv8 [27]; and CD4+ Th2 T cells increase angiogenesis via interleukin secretion and recruitment of M2-like tumour-associated macrophages [32]. This evidence concerns the gene VEGFA and neoplasm.