Shifting to oligodendrogliomas (grade 2 and 3), key genetic alterations include Telomerase Reverse Transcriptase (TERT) promoter mutation (96%), Capicua Transcriptional Repressor (CIC) mutation (62%), Far Upstream Element Binding Protein 1 (FUBP1) mutation (29%) and Notch homolog 1(NOTCH1) overexpression (31%) [5,12]. The gene discussed is CIC; the disease is oligodendroglioma.