Vice versa, we observed six overlapping genes/proteins (ANP32E, ANXA5, NUCB2, PSMB3, RER1, and TPD52) that are upregulated upon TMP269 treatment in MOLM-13 cells but are expressed at lower transcriptional levels in AML patients (Supplementary Figure S1B). Here, RER1 is linked to acute myeloid leukemia.