According to a study on the migratory effect of NTN-1 in a 3D cell culture model of liver cancer cells, NTN-1 increased N-cadherin-mediated cell junctions (a hallmark of epithelial-to-mesenchymal transition) and promoted cell migration, while NTN1 silencing decreased N-cadherin and inhibited cell migration, revealing that the ability of NTN-1 to enhance migration may also increase the metastasis of liver cancer. This evidence concerns the gene CDH2 and liver cancer.