In this line, the expression levels of Ntn1 were upregulated in the colon from mice containing a germline mutation in the adenomatous polyposis coli (Apc) gene, as well as in azoxymethane and dextran sulphate models of colitis-associated colon cancer (CC), inhibiting colonic epithelial cell apoptosis and promoting the development of high-grade colon adenomas [10,18]. Here, APC is linked to colon adenoma.