In this line, the importance of NTN-1 on the formation of intracellular fibres for cell contraction and motility in a human colon carcinoma cell line has been described, with greater cell retraction and an increase in actin filaments along the cell margins, further supporting the migratory effect of NTN-1 on tumour cells [50]. This evidence concerns the gene NTN1 and colon carcinoma.