TNF and head and neck squamous cell carcinoma: cIAP inhibition has also been reported to inhibit RIP1 polyubiquitination and canonical IKK-NFκB/RELA prosurvival signaling, while promoting the stabilization of NFκB-inducing kinase (NIK) and non-canonical NFκB2/RELB transcription of TNFα [13,14], but these effects have not been demonstrated in HNSCC.