Our data demonstrate the susceptibility of a panel of HNSCC cancer cell lines with different mutational profiles and HPV status to combined inhibition of IAP and WEE1 in the presence of TNFα, an inflammatory cytokine produced in the tumor microenvironment by immune cells, stomal, and tumor cells when induced by ionizing radiotherapy [6,59]. This evidence concerns the gene TNF and head and neck squamous cell carcinoma.