It has been shown previously in in vitro glioma models that ASIC1 colocalizes and works in tandem with ENaC subunits to facilitate glioma migration [86], an interaction that might have been disrupted upon treatment with amiloride and further decreased cellular invasion in proneural-like U87-MG cells compared to classical-like U251-MG cells. This evidence concerns the gene ASIC1 and central nervous system cancer.