HMGB1 and hepatocellular carcinoma: Indeed, HMGB1 has been implicated in the progression of a wide range of human cancers including NSCLC, pancreatic ductal adenocarcinoma, metastatic breast cancer, ovarian cancer, hepatocellular carcinoma, colorectal cancer, metastatic melanoma, mesothelioma, and gastric cancer (reviewed in [71]).