VEGFA and neoplasm: Activation of RAGE within the TME results in multiple pro-tumor activities including (i) enhancing cancer cell invasion, dissemination, and metastasis; (ii) remodeling of the extracellular matrix to provide a scaffold for supporting tumor progression; (iii) driving inflammation that supports tumor progression and invasion; (iv) upregulating VEGF to support neo-angiogenesis; (v) metabolic reprogramming to favor growth in the hypoxic TME; (vi) counteracting genomic instability by supporting DNA repair; and (vii) driving and sustaining immune suppression (reviewed by [98]).