Using IF for CD31 (endothelial cell marker), desmin (perivascular cell markers), and CA-IX (hypoxia marker), we found a site-dependent effect on tumor vasculature and hypoxia in response to CXCR4 inhibition, with statistically significant changes or strong trends only in the metastatic PCa lesions (Figure 5). The gene discussed is PECAM1; the disease is posterior cortical atrophy.