BIRC5 and cancer: Several of these include the missense variants rs1042489 in the 3’ untranslated region; rs8073069, rs17878467, and rs9904341 located in the promoter; and the missense variant rs2071214 in exon 5, for which the relationship between survivin mutations and cancer susceptibility in various populations has been evaluated in numerous studies [32,33,34,35,36].