In addition, studies by Yan et al. showed that linc00355 was highly expressed in cancer-associated fibroblast exosomes, and exosome-mediated linc00355 transfer promotes BLCA cell proliferation, invasion and chemotherapy resistance via miR-34b-5p/ATP binding cassette subfamily B member (ABCB1) and the miR-15a-5p/HMGA2 axis [87,88,89]. This evidence concerns the gene HMGA2 and bladder transitional cell carcinoma.