As tumor invasion, metastasis, and therapeutic resistance are closely related to epithelial–mesenchymal transition (EMT), Yang et al. assessed the effect of the combination use of these two drugs on EMT, finding that the cotreatment had a synergistic effect on suppressing EMT by upregulating the epithelial cell marker E-cadherin and downregulating the mesenchymal cell markers Vimentin and Snail, suggesting that inhibition of the EMT process may be considered as another possible mechanism via which enalapril potentiates the antitumor effect of 5-FU in CRC. The gene discussed is CDH1; the disease is colorectal carcinoma.